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Comparative and demographic analysis of orang-utan genomes


We estimated nucleotide divergence in unique gap-free sequence, indicated at each node, from the alignment of rhesus macaque (yellow), gibbon (purple), orang-utan (orange), gorilla (aqua), chimpanzee (green) and human (blue) whole genome shotgun reads to the human reference (Hs.35; Supplementary Information section 3). Note that the Bornean (P. pygmaeus) and Sumatran (P. abelii) orang-utan species showed nucleotide identity comparable to that of bonobo (Pan paniscus) and chimpanzee (Pan troglodytes). Estimates of divergence time based on sequence identity are indicated at each node, ~1Myr implies approximately 1Myr or less. Values taken from refs 29 and 30 where indicated.



We identified six genes (indicated in yellow) under moderate to strong positive selection in primates (P<0.05) that fall within the cerebroside-sulphatid region of the sphingolipid metabolism pathway (adapted from human KEGG pathway 00600). This pathway is associated with several human lysosomal storage disorders, such as Gaucher’s disease, Sandhoff’s disease, Tay-Sachs disease and metachromatic leukodystrophy. Abbreviations, annotations and connections are presented in accordance with KEGG standards: solid lines represent direct relationships between enzymes (boxes) and metabolites (circular nodes), dashed lines represent indirect relationships, arrowheads denote directionality (see http://www.genome.jp/kegg-bin/show_pathway?map00600 for further details).


Le chaînon Ida





Réalisation : Arno Caravel

Production : universcience.tv

Date de production : 2010

de Colin Tudge,
Éd. J.-C. Lattès, 2009.
Véritable enquête sur la découverte et l’étude d’Ida, fossile de 47 millions d’années, à l’origine de percées spectaculaires dans la recherche sur les ancêtres des primates.

Pour découvrir tous les livres de cette série aller dans MENU (sous la vidéo).



Climate Change and Human Evolution Video | Smithsonian Human Origins Program

The Neandertal Genome – Background


The Neandertal Genome Because Neandertals are much closer kin to us than are chimpanzees, which diverged from the human lineage 5 to 7 million years ago, matching Neandertal DNA against our own has the potential to reveal genetic changes that help define who we are. http://www.sciencemag.org/special/neandertal/feature/index.html


Neanderthal genes ‘survive in us’




Exploratorium | Evidence | How Do We Know What We Know? | Human Origins



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