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Cell – COLLECTIONS-RNA-Genome-Stability





Cells must control transposons and foreign genetic elements to maintain genomic stability. This is especially important in gametes, where unchecked transposon activity could affect the next generation. We now know that organisms have pathways in which small RNAs guide proteins to actively silence transposons in the genome. These pathways exist in prokaryotes and eukaryotes, with general mechanisms conserved between the two groups. These include mechanisms for recognizing foreign genetic elements, activating the silencing responses, and maintaining a “memory” of the active transposon event. Small RNAs associated with piwi proteins — known as piRNAs — are critical to these processes.

In 2007, Brennecke et al. proposed that the piRNA pathway could act as a molecular adaptive immune system, capable of sensing and reacting to adaptive transposons by silencing them. We begin this Collection looking back at these findings and then taking a broader view to appreciate how much we have learned about the roles of small RNAs in the maintenance of genomic stability.

Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila.
Julius Brennecke, Alexei A. Aravin, Alexander Stark, Monica Dus, Manolis Kellis, Ravi Sachidanandam, Gregory J. Hannon

SnapShot: Mouse piRNAs, PIWI Proteins, and the Ping-Pong Cycle
Jogender S. Tushir, Phillip D. Zamore, Zhao Zhang





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