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The RNA Enigma

 

The RNA Enigma.

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine | eLife

 

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine | eLife.

The Origins and Evolution of the Ribosome

via The Origins and Evolution of the Ribosome.

Genomic differences between individuals can change the physical organization of RNA transcripts

The information contained within a messenger RNA (mRNA) transcript goes beyond the protein recipe embedded in its sequence. mRNAs consist of single strands of nucleotides that can pair with each other in the same way as double-stranded DNA molecules. The resulting ‘secondary structures’ help determine when and how the encoded protein gets produced.

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A mutation in the H/ACA box of telomerase #RNA component gene (TERC) in a young patient with myelodysplastic… http://t.co/L8XgdSlb94 #BMC

A mutation in the H/ACA box of telomerase #RNA component gene (TERC) in a young patient with myelodysplastic… http://t.co/L8XgdSlb94 #BMC

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The energetic origins of life – Phys.Org


Phys.Org
The energetic origins of life
Phys.Org
While most acetogens are classified as bacteria, the methanogens belong to kingdom Archaea. This domain was only recently classified as distinct from bacteria and eukaryotes in 1977 by the late Carl Woese. Methogens are key to a bold leap of thought …

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The T box riboswitch: A novel regulatory RNA that utilizes tRNA as its ligand.

The T box riboswitch: A novel regulatory RNA that utilizes tRNA as its ligand.

Biochim Biophys Acta. 2014 May 7;

Authors: Henkin TM

Abstract
The T box riboswitch is a cis-acting regulatory RNA that controls expression of amino acid-related genes in response to the aminoacylation state of a specific tRNA. Multiple genes in the same organism can utilize this mechanism, with each gene responding independently to its cognate tRNA. The uncharged tRNA interacts directly with the regulatory RNA element, and this interaction promotes readthrough of an intrinsic transcriptional termination site upstream of the regulated coding sequence. A second class of T box elements uses a similar tRNA-dependent response to regulate translation initiation. This review will describe the current state of our knowledge about this regulatory system. This article is part of a Special Issue entitled: Riboswitches.

PMID: 24816551 [PubMed - as supplied by publisher]

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Abiogenesis

Abiogenesis.

David Bartel Whitehead Institute/MIT/HHMI: MicroRNAs: Introduction to MicroRNAs

 

David Bartel Whitehead Institute/MIT/HHMI Part 1: MicroRNAs: Introduction to MicroRNAs.

Indyplus video: Crispr technique – Science – News – The Independent

Indyplus video: Crispr technique – Science – News – The Independent.

Author Grid

@RNomics

RSS RNomics RNA TWT

  • World's Richest Doctor Buys World's Most Powerful DNA Sequencer - Forbes August 1, 2014
    forbes.com This morning, Patrick Soon-Shiong, the surgeon-turned entrepreneur that Forbes estimates is worth $10.1 billion, announced that his company and foundation are purchasing a cluster of DNA sequencers capable of sequencing a human genome for $1,000. The purchase is part of a deal between Providence Health Services, a not-for-profit Catholic hospitals […]
  • Twitter / BiochemPhD: My experiments play jokes on ... August 1, 2014
    twitter.com posted by friends:  (1) @BiochemPhD: My experiments play jokes on me. #ScienceProblems pic.twitter.com/UuA3mlkRAM 01.08.2014 09.11.40 posted by followers of the list:  (0)
  • Gene therapy biotech Avalanche banks $102M in an up-sized IPO - FierceBiotech August 1, 2014
    fiercebiotech.com Menlo Park, CA's Avalanche Biotechnologies pulled off a $102 million Wall Street debut, planning to spend its new cash on a pipeline of gene therapies for ocular diseases. posted by friends:  (1) @RNAiAnalyst: Gene therapy biotech Avalanche banks $102M in an up-sized IPO - FierceBiotech: fiercebiotech.com/story/gene-the… 01.08.2014 09. […]
  • Uncoupling of the dynamics of host–pathogen interaction uncovers new mechanisms of viral interferon antagonism at the single-cell level August 1, 2014
    nar.oxfordjournals.org posted by friends:  (1) @NAR_news: Uncoupling of the dynamics of host-pathogen interaction uncovers new mechanisms of viral interferon antagonism... bit.ly/1oaA0P4 01.08.2014 03.32.54 posted by followers of the list:  (0)
  • Ebola rages in Africa as west agonises over ethics of vaccine and drug testing | Society | The Guardian August 1, 2014
    theguardian.com - Sarah Boseley, health editor If there are to be vaccines and drugs against Ebola, trials in outbreaks will have to be done In 2002, scientists writing in a leading American medical journal discussed the possibility that the Ebola virus could be used in a biochemical weapon. It would be technically difficult and unlikely to cause mass destru […]
  • New NASA Research Shows Giant Asteroids Battered Early Earth | NASA August 1, 2014
    nasa.gov New research shows that more than four billion years ago the surface of Earth was heavily reprocessed – or melted, mixed, and buried – as a result of giant asteroid impacts. posted by friends:  (1) @BurkeLabRNA: Late heavy bombardment supported by latest models of early Earth at 4.0-4.5 Gya. go.nasa.gov/1k9HFhd    pic.twitter.com/0wBr3OP3jI via @nas […]
  • Twitter / NASA: New research shows giant ... August 1, 2014
    twitter.com posted by friends:  (1) @BurkeLabRNA: Late heavy bombardment supported by latest models of early Earth at 4.0-4.5 Gya. go.nasa.gov/1k9HFhd    pic.twitter.com/0wBr3OP3jI via @nasa 01.08.2014 07.04.33 posted by followers of the list:  (0)
  • Twitter / BloombergNews: World Health Organization and ... August 1, 2014
    twitter.com posted by friends:  (1) @RNAiAnalyst: World Health Organization and West African states to pump $100 million into #Ebola effort: bloom.bg/1nKtG1j pic.twitter.com/Yo3Djbgtr5 31.07.2014 23.19.18 posted by followers of the list:  (0)
  • Ebola Deaths Rise as Quarantines Seek to Limit Disease - Bloomberg August 1, 2014
    bloomberg.com The presidents of Sierra Leone and Liberia took drastic actions to control citizen movements in their countries and global health officials promised to send more help to West Africa as the Ebola death toll rose to 729, or 57 more than a week earlier. posted by friends:  (1) @RNAiAnalyst: World Health Organization and West African states to pump […]
  • Sarepta Therapeutics Inc - Investors - News Release August 1, 2014
    investorrelations.sarepta.com posted by friends:  (1) @RNAiAnalyst: $SRPT drama continues -> BoD Chariman William Goolsbee resigned, John Hodgman named as interim chairman investorrelations.sarepta.com/phoenix.zhtml?… 01.08.2014 01.30.58 posted by followers of the list:  (0) […]

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