The information contained within a messenger RNA (mRNA) transcript goes beyond the protein recipe embedded in its sequence. mRNAs consist of single strands of nucleotides that can pair with each other in the same way as double-stranded DNA molecules. The resulting ‘secondary structures’ help determine when and how the encoded protein gets produced.
The energetic origins of life
While most acetogens are classified as bacteria, the methanogens belong to kingdom Archaea. This domain was only recently classified as distinct from bacteria and eukaryotes in 1977 by the late Carl Woese. Methogens are key to a bold leap of thought …
The T box riboswitch: A novel regulatory RNA that utilizes tRNA as its ligand.
Biochim Biophys Acta. 2014 May 7;
Authors: Henkin TM
The T box riboswitch is a cis-acting regulatory RNA that controls expression of amino acid-related genes in response to the aminoacylation state of a specific tRNA. Multiple genes in the same organism can utilize this mechanism, with each gene responding independently to its cognate tRNA. The uncharged tRNA interacts directly with the regulatory RNA element, and this interaction promotes readthrough of an intrinsic transcriptional termination site upstream of the regulated coding sequence. A second class of T box elements uses a similar tRNA-dependent response to regulate translation initiation. This review will describe the current state of our knowledge about this regulatory system. This article is part of a Special Issue entitled: Riboswitches.
PMID: 24816551 [PubMed - as supplied by publisher]